采用响应面分析法优化丙烯酸十六酯的合成工艺条件.在单因素实验的基础上,通过Box-Behnken中心组合实验,考察催化剂用量、阻聚剂用量和反应温度三因素及其相互作用对酯化率的影响,得出丙烯酸与十六醇反应的最佳酯化条件.实验结果表明,催化剂用量与反应温度间的相互作用最大,催化剂用量与阻聚剂用量的相互作用最小;最佳工艺条件为:催化剂对甲苯磺酸用量(质量分数)2.05%～2.20%、阻聚剂对苯二酚用量(质量分数)0.6%～0.7%、反应温度120～125℃,在此条件下酯化率可达93%以上;并得出酯化率的二次多项回归模型,可根据同归模型对酯化反应进行控制.%Response surface method(RSM) was used to optimize the synthesis process for hexadecyl acrylate from acrylic acid and hexadecanol. Based on the single factor experiments ,Box-Behnken central composite design was adopted to investigate the influences of catalyst dosage, polymerization retarder dosage,reaction temperature and their interactions on the esterification. Then the optimal conditions for the esterification were obtained by RSM. The interaction between the catalyst dosage and the reaction temperature was the strongest. Under the optimal conditions of catalyst toluene-p-sulfonic acid dosage 2.05％ -2.20％ (based on the total reactant mass, the same below ), polymerization retarder hydroquinone dosage 0.6％ - 0.7％ and reaction temperature 120 - 125 ℃, the ester yield could reach more than 93％. A quadric polynomial regression model was established, in which the coefficient of determination R2 was 0. 925 2. The esterification process could be controlled by the regression model.
展开▼
