Objective To study the efficacy and safety of laparoscopy assisted distal radical gastrectomy and open radi -cal operation for gastric cancer .Methods 90gastric cancer patients were divided into the observation group treated with laparos-copy assisted operation and the control group treated with open operation .The operation related index , serum c-reactive protein (CRP),carcinoembryonic antigen (CEA),carbohydrate antigen 72-4 (CA72-4),and postoperative index were observed .Results There had no statistical difference between the 2 groups in operation time and margin-focal distance;bleeding amount (101.6 ± 13.9)ml,CRP (15.7 ±6.3)mg/L,CEA (6.2 ±1.4)ng/ml,CE72-4 (9.5 ±3.2)U/ml,exhaust time (3.3 ±0.6)d,postopera-tive eating time (3.8 ±1.1)d,analgesic usage (4.2 ±0.7),hospitalization time (10.6 ±2.4)d of the observation group were significantly less than those of the control group;while number of lymph node dissection (18.4 ±3.2) of the observation group was significantly more than that of thecontrol group .Conclusion Laparoscopic surgery can effectively clean lymphocyte ,reduce surgi-cal trauma ,improve gastrointestinal function ,promote prognosis ,it is an effective and safe treatment for gastric cancer .%目的：探讨腹腔镜辅助远端胃癌根治术与开腹根治术的临床疗效和安全性。方法将90例远端胃癌患者随机分为给予腹腔镜手术的观察组和开腹手术的对照组，观察术中相关指标、血清C反应蛋白（ CRP ）、癌胚抗原（CEA）、糖类抗原72-4（CA72-4）、术后恢复指标。结果2组患者在手术时间、切缘与病灶的距离方面的差异无统计学意义；观察组术中出血量（101．6±13．9）ml、CRP（15．7±6．3）mg/L、CEA（6．2±1．4）ng/ml、CE72-4（9．5±3．2）U/ml、术后肛门首次排气时间（3．3±0．6）d、术后进食时间（3．8±1．1）d、镇痛药使用次数（4．2±0．7）、总住院时间（10．6±2．4）d明显低于对照组；淋巴结清扫数目（18．4±3．2）明显多于对照组（P＜0．05）。结论腹腔镜手术能有效进行淋巴结清扫、减小手术创伤、促进术后胃肠功能恢复、改善患者预后，是治疗胃癌有效、安全的方式。
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