动脉粥样硬化(AS)是由多种因素共同作用而导致的慢性炎性反应.血管平滑肌细胞(VSMCs)迁移是AS、冠状动脉血管成形术后再狭窄等的重要病理基础.藁本内酯是一种主要从中药川芎、当归等伞形科植物中提取的代谢成分和主要活性物质,具有抗炎、抗氧化等多种药理活性,可通过调控原癌基因c-Myc和黏着斑激酶(FAK)信号通路等途径而抑制VSMCs迁移,防止心血管疾病的发生、发展.本文综述了藁本内酯对AS患者VSMCs迁移的影响及其作用机制的研究进展,旨在为心血管疾病的防治提供参考.%Atherosclerosis(AS)is one kind of chronic inflammatory reactions caused by combined action of multiple factors.Vascular smooth muscle cells(VSMCs)migration plays an important role in AS and restenosis after coronary angioplasty.Ligustilide is the major active material extracted from ligusticum chuanxiong and angelica sinensis,has various pharmacological activities(such as anti-inflammatory effect and anti-oxidation effect),can inhibit the VSMCs migration by regulating protooncogene c-Myc and FAK signal pathway,is helpful to prevent the development and progression of cardiovascular disease.This paper reviewed the progress on impact of ligustilide on VSMCs migration of patients with AS and the mechanism,to provide references for prevention and treatment of cardiovascular disease.
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