Objective To investigate the clinical efficacy of hemodialysis and naloxone treatment of acute severe alcoholism. Methods The 92 cases of severe acute alcoholism were randomly divided into two groups,the control groups and the observation group;46 cases of the observation group were treated with naloxone and hemodialysis treatment,46 patients in the control group only with naloxone. Clinical efficacy,clinical symptoms improved time,hospitalization time,glutamic acid aminotransferase (ALT) levels change and the incidence of complications. Results 1)Total effective rate of the observation group was higher than that of the control group, the difference between the two groups was statistically significant(P<0.05). 2)Symptoms and recovery time,hospital stay time of the observation group were shorter than that of the control group,the difference was statistically significant (P<0.05). In ALT levels before treatment,the difference was not statistically significant,after the treatment,ALT levels of the observation group was lower than that of the control group,the difference was statistically significant (P<0.05). 3)In the observation groups the probability of patients with liver and kidney dysfunction,with aspiration pneumonia and pancreatitis was less than in the control group,there were significant differences between the two groups (P<0.05). Conclusion Naloxone plus hemodialysis treatment of severe acute alcoholism has significant effect and can quickly improve the clinical symptoms,reduce the incidence of complications.%目的：观察纳洛酮与血液透析治疗急性重度酒精中毒的临床疗效。方法将92例急性重度酒精中毒患者随机分为观察组与对照组，观察组46例采用纳洛酮与血液透析治疗，对照组46例仅采用纳洛酮治疗。比较两组患者的临床疗效、临床症状改善时间、住院时间、丙氨酸氨基转移酶（alanine aminotransferase，ALT）水平变化及并发症的发生情况。结果（1）观察组的治疗总有效率高于对照组（97.8% vs 82.6%），组间存在统计学差异（χ2=6.035，P<0.05）。（2）观察组的清醒时间、症状消失时间和住院时间均短于对照组，差异均有统计学意义（P<0.05）。两组患者治疗前ALT水平无统计学差异，但观察组治疗后的ALT水平显著低于对照组，差异有统计学意义（t=14.859，P<0.05）。（3）观察组患者发生肝肾功能异常、吸入性肺炎和胰腺炎的概率小于对照组，差异均有统计学意义（P<0.05）。结论应用纳洛酮与血液透析救治急性重度酒精中毒疗效显著，可缩短临床症状的改善时间，降低并发症发生率。
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