Objective To compare the effect of different-dose sufentanil combined with 0.1%ropivacaine on epidural analgesia for labor pain relief. Method The 80 nulliparous in term parturients were randomized to receive 0.1% ropivacaine with fentanyl (2μg.ml-1) or sufentanil (0.2μg.ml-1, 0.4μg.ml-1,0.6μg.ml-1) through patient-controlled epidural analgesia. Maternal analgesia assessed by visual analog scale (VAS) were recorded before and after epidural block. The duration of the first and second labor course as well as newborn's weight were observed. Result The VAS score with higher dose of sufentanil (0.4μg.ml-1, 0.6μg.ml-1) was significantly lower than that of with fentanyl (2μg.ml-1) at 10 minute after epidural block, but no significant difference at 30 and 60 minute after epidural block.There was no difference in the duration of first and second labor course. Conclusion The dosage of 0.1%ropivaeaine with 0.2-0.4μg.ml-1 sufentanil is suitable for patient-controlled epidural analgesia for labor pain relief.%目的 探讨分娩镇痛中舒芬太尼和低浓度罗哌卡因配伍的合适剂量.方法 80例足月妊娠单胎初产妇,年龄20～32岁.随机分为四组:0.1%罗哌卡因复合芬太尼2μg/mL组(F组);0.1%罗哌卡因复合舒芬太尼0.2μg/ml组(S1组);0.1%罗哌卡因复合舒芬太尼0.4μg/ml组(S2组);0.1%罗哌卡因复合舒芬太尼0.6μg/ml组(S3组).对镇痛效果、产程变化、运动神经阻滞程度、新生儿体重及Apgar评分等项目进行观察.结果 S2、S3组在麻醉后10min时VAS评分较低,与F组、S1组相比有差异;各组在麻醉后30、60min时VAS评分无差异:S3组皮肤瘙痒发生率明显增加;第一、二产程,新生儿体重及Apgar评分四组无差异.结论 舒芬太尼0.2～4μg/ml复合0.1%罗哌卡因行硬膜外镇痛分娩是比较合适的剂量.
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