长链非编码RNA(Long noncoding RNA,LncRNA)是一类不能编码翻译蛋白质的长度大于200个核苷酸的RNA,它能够通过与DNA、RNA或蛋白质结合,参与X染色体沉默、染色质修饰、转录激活、转录干扰等调控过程.近年来越来越多研究证实,其在胃癌的发生发展和侵袭转移中发挥作用.与此同时,以LncRNA为靶点的中药抗胃癌恶性行为研究逐年增多,本文介绍了LncRNA在胃癌恶性行为调控中的作用机制及以此为靶点的中药治疗前景.%Long non-coding RNA(LncRNA)is a class of RNA that cannot encode translated proteins with more than 200 nucleotides in length.It can be involved in the regulation of X chromosome silencing,chromatin modification,transcriptional activa-tion,transcriptional interference and other regulatory processes by binding to DNA,RNA or proteins.In recent years,more and more studies have confirmed that LncRNA plays an important role in the occurrence,development,invasion and metastasis of gastric cancer. At the same time,many studies have demonstrated LncRNA as the target of traditional Chinese medicine for the development and pro-gression of anti-gastric cancer.This review introduces the mechanism of LncRNA in the development and progression of gastric canc-er,and as a target for traditional Chinese medicine treatment prospects.
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