药物代谢酶的基因多态性可能导致个体甲氨蝶呤疗效及不良反应的不同.尽管近年来化疗方案在不断优化,抗肿瘤药物不良反应仍可能导致化疗不能正常进行,有时甚至危及生命.检测候选基因多态性可增加治疗的安全性,可能有助于指导个体化用药.%Gene polymorphism in drug-metabolizing enzymes may cause individual differences in the effectiveness and toxicity of methotrexate.Although the chemotherapy regimens for childhood acute lymphoblastic leukemia have been improved in recent years,many adverse effects resulting from anti-cancer drugs may cause the interruption of chemotherapy.Some severe ones are even life-threatening.Determining the polymorphisms of selected genes may increase the safety of the chemotherapy,and may help develop individualized therapies.
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