Objective:To observe efficacy evaluation and safety analysis of the use of oral hypoglycemic drugs for the treatment of poor control of blood sugar in type 2 diabetes patients with initializing basal insulin treatment. To better guide clin-ical diabetes treatment. Methods:Selection of oral hypoglycemic drugs poor control blood sugar,and agreed to begin to accept basal insulin treatment of 102 patients with type 2 diabetes,interview all subjects for the three month and the six month,visits included situation of medication,Blood glucose self - monitoring and adverse reaction,testing glycosylated hemoglobin (HbA1c)and fasting plasma glucose(FPG). Results:Included in the study subjects were 102 cases,100 cases completed 6 months' follow - up,2cace were lost. After Basal insulin treatment six months HbA1c and FPG was decline,differences are sta-tistically significant,HbA1c decreased and HbA1c,FPG before treatment were positively correlated. After treatment HbA1c standards are 23 cases(23. 0% ),HbA1c descend range - 1. 5% ~ 4. 0% ,The effective rate of therapy was 61. 0% . 3 cases have 5 times of daily sympotomatic hypoglycemia,Symptoms remission after eating sugary foods. Conclusion:Initial insulin ther-apy decrease level of HbA1c and FPG effectively in oral hypoglycemic drugs poor control blood sugar with type 2 diabetes,but the time of patients initializing basal insulin was late,and dose of basal insulin changed less,we don't have good control of HbA1c. The use of oral hypoglycemic drugs for the treatment of poor control of blood sugar in type 2 diabetes patients should initiate standard use basal insulin early.%目的：观察口服降糖药物血糖控制不佳的2型糖尿病患者起始基础胰岛素治疗的疗效及安全性，以更好地指导临床糖尿病治疗。方法：选取口服降糖药物血糖控制不佳，并同意接受起始基础胰岛素治疗的2型糖尿病患者102例，对所有受试者进行第3个月和第6个月访视，并检测糖化血红蛋白（HbA1c）和空腹血糖（FPG），访视内容包括患者用药、血糖自我监测及不良反应等。结果：102例中100例完成研究，2例失访。起始基础胰岛素治疗后 HbA1c和 FPG 均下降（P ﹤0.05），差异有统计学意义。基础胰岛素治疗后 HbA1c 下降幅度与治疗前 HbA1c，FPG 呈正相关。治疗后 HbA1c 达标者23例，达标率23.0％，HbA1c 下降幅度分布在-1.5％~4.0％之间，治疗有效率为61.0％。治疗期间共有3例受试者发生5次日间症状性低血糖，进食含糖食物后症状缓解。结论：基础胰岛素治疗可有效降低口服降糖药血糖控制不佳的2型糖尿病患者的空腹血糖及糖化血红蛋白，低血糖发生率低，但起始基础胰岛素治疗较晚，治疗后整体达标率不高，口服降糖药血糖控制不佳的2型糖尿病患者要在早期启用规范化基础胰岛素治疗。
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