Technetium based radiopharmaceuticals have been widely used in scientific research and clinic.A large amount of new radiopharmaceuticals have been exploited and used.However,how to develop pharmaceuticals with better treatments and wider applicability to meet the need of clinic is still an urgent problem.The introduction of new ligands and cores and development of new strategies for labeling have become a hot subject in the technetium based radiopharmaceutical field.In order to provide some references to the researchers,introduction of some new labeling methods for technetium-99m-labeled radiopharmaceuticals,including new ligands and methods for 99mTc-tricarbonyl technetium labeling,preparation and application of the high-valent technetium,are given in this paper.%99mTc放射性药物在科学研究和临床上已经得到了广泛的应用,但如何发展药效更好的药物以适应临床诊断的需求,依然是亟待解决的问题。新药物配体和金属核的引入以及新的标记方法的发展是目前99mTc放射性药物研究的热点。本文介绍99mTc放射性药物化学的几种新标记方法,包括羰基锝标记的新型配体和新方法9、9mTc高价配合物的制备和应用等,旨在对有关研究者提供参考。
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