Objective:To investigate the association between exhaled nitric oxide levels (FeNO) and airway hyperresponsiveness (AHR) in children with chronic persistent asthma.Methods:72 cases of children with chronic persistent asthma in our hospital were selected and divided into the hormone treatment group and non hormone treatment group according to whether inhaled corticosteroids were applied.36 cases in thenon hormone therapy group were given routine asthma drugs (compound Tuoyingmahuangchajian tablet) treatment,36 cases in the hormone therapy group were given corticosteroid therapy based on the non hormone therapy group (Fluticasone Propionate Inhaled Aerosol),40 cases of healthy children in our hospital for examination were selected as the control group.After treatment,the exhaled FeNO level and AHR index were compared among 3 groups of children.Results:(1) The exhaled FeNO level of non hormone therapy group was higher than that of the hormone therapy group and control group (P＜0.05),the exhaled FeNO level of hormone treatment group was higher than that of the control group (P ＜ 0.05);(2)No significant difference was found in the 50％ vital capacity of maximal expiratory flow variation rate (MEF50 value) between hormone treatment group and non hormone therapy group (P＞0.05);(3)The first second forced expiratory volume variation rate (FEV1 value) of non hormone treatment group was significantly higher than that of the hormone treatment group(P＜0.01);(3)The FeNO level of children in the hormone treatment group was positively correlated with the delta MEF50 and delta FEV1 value(P＜0.05),the correlation coefficients were 0.526 and 0.485;the FeNO level of non hormone therapy group and control group showed no correlation with the delta MEF50 and delta FEV1 value (P＞0.05).Conclusion:Glucocorticoids can effectively control the clinical AHR OF children with chronic persistent asthma,FeNO and AFEV1 were significantly correlated woth exhaled and AMEF50 values,which may be used as clinical evaluation reference of children with asthma airway responsiveness.%目的:探讨慢性持续期哮喘患儿呼出一氧化氮水平(FeNO)与气道高反应性(AHR)的相关性.方法:选取我院收治的慢性持续期哮喘患儿72例,依据是否应用吸入性糖皮质激素药物分为激素治疗组和非激素治疗组.非激素治疗组患儿36例给予常规哮喘药物(复方妥英麻黄茶碱片)治疗,激素治疗组患儿36例在非激素治疗的基础上加用糖皮质激素药物(丙酸氟替卡松吸入气雾剂)治疗,另选取同期到我院进行相关检查的40例健康儿童作为对照组.疗程结束后检测3组患儿呼出FeNO水平及其AHR指标,并进行相关的统计学分析.结果:(1)非激素治疗组呼出的FeNO水平显著高于激素治疗组和对照组(P＜0.05),激素治疗组呼出的FeNO水平明显高于对照组(P＜0.05);(2)激素治疗组患儿与非激素治疗组50％肺活量最大呼气流量变异率(△MEF50值)比较无显著差异(P＞0.05);非激素治疗组患儿第一秒用力呼气容积变异率(△FEV1值)显著高于激素治疗组(P＜0.01);(3)激素治疗组患儿呼出的FeNO水平与△MEF50值和△FEV1值具有显著正相关性(P＜0.05),相关系数分别为0.526、0.485;非激素治疗组以及对照组患儿FeNO水平与△MEF50值和△FEV1值无相关性(P＞0.05).结论:应用糖皮质激素对慢性持续期哮喘患儿进行规范化治疗能够有效控制其临床AHR,患儿呼出的FeNO水平与AFEV1值和AMEF50值均具有显著相关性,可能作为评价哮喘患儿气道反应性的临床指标.
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