Hormone-sensitive lipase (HSL)has long been considered as a classical rate-limiting enzyme during lipolysis since it was first described in 1 960s.HSL is regulated mainly by catecholamine,inclu-ding adrenalin.Studies in recent years indicated that the substrates for HSL are not only triglycerides, but also diacylglycerol with the catalytic activity is ten times that of triglycerides,glycerol esters and cho-lesterol esters,which overthrow the opinion that HSL is specific to triglyceride.The scientists have gener-ated HSL gene knockout mice and confirmed HSL is widely located in the reproductive system,which in-dicates that HSL may play an important role in the regulation of physiological and pathophysiological process in the reproductive system.Here,we will focus on the features of the HSL gene,mRNA and its protein,and summarize the HSL functions in the reproductive system.%激素敏感性脂肪酶被认为是经典的脂肪分解限速酶，可特异水解甘油三酯，受儿茶酚胺等激素调控。近年来研究表明：HSL 作用底物不仅有甘油三酯，还包括甘油二酯、甘油一酯、胆固醇酯等。然而，脂肪酶在生殖系统的功能并不清楚，基因敲除小鼠为证实 HSL 广泛存在于生殖系统提供良好模型，提示其可能在生殖系统生理及病理生理过程发挥重要调节作用，本文将着重介绍生殖系统中 HSL 基因与蛋白质结构并总结其在生殖系统的功能。
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