Several methods including holding ,soaking ,brushing and paper binding are employed in experim-ents to eliminate mechanically induced signal (MIS ) in nail slices .The resulted EPR spectrums are then com-pared to determine the appropriate MIS elimination method ,with operation time taken into account at the same time .Paper binding ,which could eliminate MIS with a simple operation ,is proven to be more suitable .This informs the application of Nail-EPR in dosimetry .%目的：通过对比不同指甲处理方法消除机械诱导信号（MIS）的优缺点，确定适宜的MIS消除方法，为指甲电子顺磁共振技术（EPR ）作为剂量计提供处理方法方面的参考。方法指甲取材后进行剪切，分别用静置法、浸泡法、毛刷法、滤纸法进行M IS消除，对比各种消除方法前后EPR图谱差异，结合各方法的操作时间，确定适宜的M IS消除方法。结果静置法效果较好，但耗时长；浸泡法效果较好，但会影响EPR正常检测；毛刷法效果较差；滤纸法效果较好，且操作便捷。结论滤纸法可基本消除MIS信号，且操作简单便捷，是较为适宜的MIS消除方法。
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