Objective To study the Xianlinggubao capsule to reduce postmenopausal osteoporosis patients with thoracolumbar compression fractures after PVP/PKP fracture risk mechanism to happen again. Methods 92 patients with PVP/PKP are randomly divided into the control group and the observation group. The control group third days after operation (d) intravenous infusion of Zoledronic Acid Injection 5 mg and add enough vitamin D and calcium, the observation group in the control group treated with clothing Xianlinggubao capsule for 46 weeks. Results Compared with the control group and the 23 weeks treatment group, the ODI, VAS scores and serum TCa levels in the observation group are significantly decreased at 23 weeks and 46 weeks, and the levels of PDGF, ALP and BMD increased significantly (P＜ 0.05). Compared with the control group, the PGE2 and PGI2 in the observation group increased significantly at 23 weeks and decreased significantly at the 46 week (P ＜0.05). The FRAX evaluation showed that low, moderate, high risk of fracture risk and FRAX index are lower than those in the control group, and the effective rate is higher than that of the control group (P ＜0.05). Conclusion Xianlinggubao capsule can improve the postoperative PVP/PKP clinical curative effect and reduce the risk of fracture.%目的 观察仙灵骨葆胶囊治疗骨质疏松胸腰椎压缩性骨折的临床疗效.方法 将92例患者随机均分为对照组和观察组, 对照组静滴唑来膦酸并补钙, 观察组在此治疗基础上加服仙灵骨葆胶囊.结果与对照组同期及本组治疗23周比, 观察组23周和46周时Oswestry功能障碍指数 (ODI) 、视觉模拟量表 (VAS) 评分及血清总钙 (TCa) 均明显降低, 血小板衍生生长因子 (PDGF) 、碱性磷酸酶 (ALP) 含量和骨密度 (BMD) 均明显升高 (P＜0.05).与对照组同期比较, 观察组23周时前列腺素E2 (PGE2) 和前列腺环素 (PGI2) 明显升高, 46周时则明显降低 (P＜0.05).骨折风险评估量表 (FRAX) 评估显示低度、中度、高度骨折风险概率及FRAX指数均低于对照组, 有效率高于对照组 (P＜0.05).结论 仙灵骨葆胶囊可提高临床疗效.
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