以可溶性淀粉为原料,研究了淀粉微球在反相悬浮体系中对阿司匹林的吸附作用.探讨了交联剂用量、引发剂用量、反应时间及搅拌速度对微球药物吸附量的影响,并考察其体外释放情况.结果表明:当交联剂用量为12 g/L,引发剂用量为3 g/L时,60℃下中速搅拌2.0h,淀粉微球对阿司匹林有较大吸附作用.在酸性条件下,阿司匹林淀粉微球在8h内有较好释放,交联剂用量对释药速率有较大影响.%Aspirin Crosslinked Starch Microspheres (Asp-CSMs) were synthesized with soluble starch as material by reversed phrase suspension method.The effects of reaction time,crosslinking agent dosage and initiator dosage on the adsorption quantity,and the stirring speed were discussed.And the release of Asp-CSMs in vitro was investigated.The results showed that the proper synthesis conditions were that:reaction time,crosslinking agent dosage and initiator dosage,and the stirring speed respectively was 2 h,12 g/L,3 g/L,moderate speed.Vitro release of the drug showed that Asp-CSMs had satisfactory releasing within 8 h under acidic condition.The dosage of crosslinking agent had greater effect to drug releasing rate.
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