研究了脱羧氯雷他定和5-甲基烟酸在氯化亚砜作用下合成卢帕他定酰胺.采用该方法合成的卢帕他定酰胺经还原反应,得到卢帕他定.该方法采用一锅法合成,缩短了工艺流程,提高了产品质量.%The synthesis of rupatadine amide was studied with Desloratadine and 5-Methylnicotinic acid with Thionyl chloride in one pot, and synthesis of the rupatadine with this rupatadine amide through reduction was proved successfully. The yield and purity of the product are improved,and the process was simplified.
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