Objective:To determine the mammographic and patient characteristics that correlate with HER-2 overexpression in primary breast carcinom .Methods:500 cases of breast cancer were included .There were 78 cases of HER-2 Overexpression(HER-2+ )breast cancer ,422 cases of without HER-2 Overexpression (HER-2-)breast canc-er .Results :Compared with the HER-2- cancer breast group ,the HER-2+ breast cancer group had a higher histologi-cal grade(P<0 .001);HER-2-breast cancer HER-2+ breast cancer group was more likely to have a lymphonodus (P<0 .001);Mammographic imaging appearances were correlated with tumor HER2 status(P<0 .001) ,indicated a significant difference .Compared with the without HER-2- breast cancer breast group ,the HER-2+ breast cancer group more likely represented simple calcification (46 .2% vs 11 .9% ,P<0 .001);Compared with the HER-2+breast cancer group ,the HER-2- breast cancer group more likely represented a simple calcification mass with calcifi-cation (37 .9% vs 16 .7% ,P<0 .001);The characteristics of mass shape were correlated with tumor HER2 status (P<0 .001) ,indicated a significant difference ,HER-2-breast cancer more likely showed oval shape(30 .5% vs 17 . 5% P<0 .05) ,the HER-2+ breast cancer more likely showed lobulated shape (42 .5% vs 13 .4% ,P<0 .001) ,Mo-reover ,the tumor mass of the HER-2+ breast cancer was more likely to have a spiculated margin (57 .5% vs 37 .3% , P<0 .05) .Conclusion :Different types of breast cancer have different biological characteristics and mammographic features .Analysis of the mammographic features may help to predict the type of breast cancer anditsprognosis ,and to select an optimaltreatment plan for patients with different types of breast cancer .%目的:研究人类表皮生长因子受体H ER2过表达在乳腺癌诊断中的价值及其与钼靶影像学特征及临床病理特征的关系.方法:收集乳腺癌患者500例,其中HER2过表达(HER-2+)型78例,HER2无过表达(HER-2-)型422例,比较两组患者的钼靶影像学表现和临床病理特征.结果:HER-2+乳腺癌组与HER-2-组比较,具有较高的病理组织学分级(P<0.001).HER-2+乳腺癌组更多表现为淋巴结阳性(P<0.001);钼靶X线检查两组差异具有统计学意义(P<0.001),其中单纯钙化肿物特征HER-2+乳腺癌组(46.2%)与HER-2-组(11.9%)比较差异具有统计学意义(P<0.001);HER-2+乳腺癌组(42.5%)多表现为分叶状肿物,与HER-2-组(13.4%)具有统计学意义(P<0.001);HER-2-组(30.5%)多发现为椭圆形肿物,较HER-2+乳腺癌组(17.5%)具有统计学意义(P<0.05);HER-2+乳腺癌组与HER-2-组肿物边缘组间比较具有统计学差异(P<0.001),HER-2+乳腺癌组(57.5%)较多变现为毛刺,较HER-2-组(37.3%)具有统计学差异(P<0.05);HER-2-组(19.1%)较HER-2+乳腺癌组光滑程度具有统计学差异(P<0.05),钙化形态HER-2+乳腺癌组(89.8%)更多表现为恶性钙化,较HER-2-组(68.5%)具有统计学差异.结论:不同类型的乳腺癌有不同的生物学特征,其钼靶影像学表现也不尽相同,了解HER-2+乳腺癌组乳腺癌的钼影像学特征,可预测乳腺癌这亚型及相关类型和患者的预后,以及评估患者对各种治疗方法的敏感性.
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