目的：探讨血浆D‐二聚体（D‐Dimer）与血浆纤维蛋白原（FIB）在局部中晚期鼻咽癌患者体内的变化趋势及关系。方法：局部中晚期鼻咽癌患者共200例，健康体检者132例作为对照组。根据年龄分为两组：即≤65岁组和＞65岁组；根据性别分为两组：男性组和女性组；再根据临床病理分期分为两组：III期组和IV期组。血浆D‐二聚体水平的检测采用免疫比浊法，而血浆纤维蛋白原的检测采用凝固法。结果：①血浆D‐二聚体及纤维蛋白原水平在局部中晚期鼻咽癌组中高于对照组（ P＜0．05）；②≤65岁组与＞65岁组相比，血浆D‐二聚体及纤维蛋白原水平在＞65岁组间浓度偏高（P＜0．05）；③血浆D‐二聚体及纤维蛋白原水平在不同性别间的差异无统计学意义；④病理分期越重，血浆D‐二聚体及纤维蛋白原水平越高，两者水平在病理分期IV组显著高于III期组（P＜0．05）。结论：鼻咽癌患者晚期的纤溶系统发生改变，年龄及病理分期越高，血浆D‐二聚体及纤维蛋白原水平越高。%Objective:To investigate the relationship of D‐Dimer and fibrinogen in patients with advanced nasopharyngeal carcinoma .Methods:Two hundred hospitalized patients were enrolled as advanced nasopharyngeal carcinoma group ,and one hundred and thirty‐two person were enrolled as control group .All the advanced nasopha‐ryngeal carcinoma patients were divided into two group by age ,over sixty five years old group and less than sixty five years old group ,and divided into two groups by gender ,and divided into two groups by pathological staging ,such III group and IV group .D‐dimer were detected by immunonephelometry method .Plasma fibrinogen were detected by freezing method .Results:The level of D‐dimer and fibrinogen were higher in advanced nasopharyngeal carcinoma group than those in control group(P<0 .05) .The level of D‐dimer and fibrinogen were higher in over sixty five years old group than those in less than sixty five years group(P<0 .05) .There was no significance in different gender .The level of D‐dimer and fibrinogen were higher in high Pathological stage .Conclusion:The level of D‐dimer and fibrino‐gen are higher in old age and high pathological stage in patients with advanced nasopharyngeal carcinoma .
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