目的：观察乳腺癌组织中钠尿素受体 A （NPRA ）的表达及与临床病理资料间的关系。方法：采用免疫组化方法对符合条件的乳腺癌50例及癌旁正常组织46例进行 NPRA 染色，并结合临床病理资料分析两者之间的相关性。结果：符合纳入标准的乳腺癌组织50例 ，癌旁正常组织46例；NPRA 在 TNM I 和 II 期中 NPRA 蛋白的强阳性表达率为36．8％（7／19），在 TNM III 期和Ⅳ期中 NPRA 的强阳性表达率为80．6％（25／31），组间比较具有统计学差异。 NPRA 蛋白表达水平与患者的发病年龄、肿瘤部位、淋巴结转移、组织分化程度、肿瘤直径大小间比较无统计学差异。 结论：NPRA 在乳腺癌组织中高表达，且与患者 TNM 分期相关。%Objective :To observe the expression of Natriuretic Peptide Receptor A (NPRA) and its rela-tionship with clinicopathological data clinical significance in the Breast Carcinomas .Methods :Using immunohisto-chemical technique to investigate the NPRA protein in eligible human breast ductal cancer and para-carcinoma speci-mens ,and analyze the relationship between NPRA expression and clinical pathological features .Results :Including 50human breast ductal cancer and 46 para-carcinoma specimens in the standard ,the positive expression of NPRA was 36 .8% (7/19)in patients of TNM I and TNM Ⅱ ,the positive expression of NPRA was 80 .6% (25/31)in pa-tients of TNM Ⅲ and TNM Ⅳ ,statistical significance was found between groups .While the expression of NPRA showed no statistically significant among the association of age ,lymph node metastasis ,tumer size ,histologic dif-ferentiation and tumer position .Conclusion :NPRA is highly expressed in patients with human breast ductal cancer , the higher positive expression of NPRA was correlation with TNM Stages .
展开▼
