目的：探讨脑源性神经营养因子（BDNF） rs6265和儿茶酚胺氧位甲基转移酶（COM T ）rs4680的多态性与广西壮族散发性帕金森病（PD）的相关性。方法：使用 PCR‐RFLP 法对112例壮族散发性 PD 患者的 rs6265和 rs4680位点进行基因分型，并与156例健康壮族老年人比较，分析这两个多态与 PD 的相关性。结果：除 PD 早发亚组 rs6265基因型 GG 的频率高于同年龄段对照组（P＜0．05），两组间的等位基因及基因型频率均无统计学差异（P＞0．05）。两位点 A 等位基因罹患 PD 的风险与正常人群无异，OR 分别为1．212（ P ＝0．572）和0．985（ P ＝0．427）。结论：rs6265和 rs4680与广西壮族散发性 PD 的遗传易感缺乏关联性。%Objectives :To investigate the correlation between BDNF rs6265 and COM T rs4680 on spo‐radic Parkinson’s disease (PD) in Zhuangs .Methods :PCR‐RFLP was employed to genotype rs6265 and rs4680 for 112 sporadic PD patients and 156 controls .Results :No difference on allelic and genotypic frequencies was found be‐tween the two groups (all P> 0 .05) under any genetic models except that the GG genotype of rs6265 was higher in the early‐onset PD subgroup as compared to controls (P< 0 .05) .Similar PD risk for A and non‐A allele carriers was found on both SNP (rs6265 :OR = 1 .212 ,P = 0 .572 ;rs4680 :OR = 0 .985 ,P = 0 .427) .Conclusions :No as‐sociation between rs6265 and rs4680 and the susceptibility of sporadic PD in Zhuangs .
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