Objective:To study the effects of pulp revascularization on the expression of bFGF and PDGF in the root tissue of young permanent dog teeth through delayed tooth replantation .Methods:4 dogs with immature teeth aged approximately 5 months were selected .The experimental group contained 11 ,13 ,15 ,41 ,43 ,45 and the teeth in other side as the control group .The replantation was proceeded 24 hours later when pulp revascularization was finished in experimental group and none treatment in control group .Statistical analysis was performed to detect bFGF and PDGF content after 3 and 6 months feed .Results:There were 3 blood clots without formation of ,7 poor MTA filling ,5 alveolar bone absorption of II or III degree and 3 root fracture .The concentration of the bFGF and PDGF in experimental group was increased and was significant different with the control group in 3 and 6 month . There was no significant difference in the experimental group on the concentration of bFGF according to the time comparison ,while the concentration of PDGF had significant different .Conclusion:Pulp revascularization is a new treatment for delayed tooth replantation .It’s a long term effect mechanism ,biology ,human tissue ,the mechanism of molecular biology and possible adverse effects still need to study for clinical application in the future .%目的：研究牙髓血运重建术对延迟再植的犬年轻恒牙根部组织碱性成纤维细胞生长因子（bFGF）及血小板衍生生长因子（PDGF）表达的影响。方法：选择4只约5月龄健康杂种犬，取11、13、15、41、43、45恒牙为实验组，对侧同名牙为对照组。1d后实验组再植后行牙髓血运重建术，对照组再植后不做附加处理。软食分笼喂养3、6月时拔除实验牙并取牙槽窝新鲜血液1m1离心，冻融后检测bFGF及PDGF含量并进行统计学分析。结果：术后实验牙有3个未形成血凝块，7个三氧化物凝聚体（MTA ）充填不佳，5个出现牙槽骨Ⅱ‐Ⅲ°吸收，3个根折。3、6个月时实验组bFGF和PDGF的浓度升高，与对照组比较差异有统计学意义，bFGF浓度无统计学差异（P＞0．05），而PD G F的浓度随时间变化呈有统计学差异。结论：牙髓血运重建术可以促使牙根发育、根尖孔闭合、根管壁增厚。但其长期疗效，生物学机制，以及可能出现的不良影响仍需继续研究。
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