目的：探讨孕母O型血清中IgG抗（A ）B抗体效价对ABO新生儿溶血的影响。方法：选取进行产前检查的198例O型Rh阳性血孕妇（丈夫为非O型Rh阳性血）及其分娩的新生儿，检测所有孕妇的Ig G抗（A ）B抗体效价，同时对新生儿进行溶血病血清学检查。结果：O‐A组孕妇血清IgG抗（A ）B抗体效价≤1∶32者8例，占9．09％，显著低于O‐B组（25．04％）和O‐AB组（25．81％ P＜0．05），而O‐B组和O‐AB组之间无显著性差异（P＞0．05）；孕妇血清IgG抗（A）B抗体效价越高，HDN发生率越高，不同抗体效价组别间比较，差异具有统计学意义（P＜0．05）。结论：孕母O型血清中IgG抗（A ）B抗体效价与ABO‐HDN 高度相关，动态监测孕母O 型血清中IgG抗（A ）B抗体效价，对预防和治疗新生儿溶血疾病具有非常重要的临床价值。%Objective:To analysis the relationship between ABO hemolytic disease of the newborn and antibody titer of IgG anti A( B) in the second trimester of the pregnant women with type O blood .Methods :198 ca‐ses of Rh O positive blood pregnant women with non‐Rh O positive blood husbands ,and their newborns were select‐ed .The titer of IgG anti‐(A) B antibody in all pregnant women was detected ,and the hemolytic disease of the new‐born was examined by serological test .Results :IgG anti‐(A) B antibody titer pregnant women in O‐A group was less than or equal to 1:32 in 8 cases ,9 .09% ,significantly lower than that in the other group (25 .04% ) and O‐AB group (25 .81% ) (P<0 .05) ,there was no significant difference between O‐B group and O‐AB group(P>0 .05) . The higher the titer of serum IgG (A) B antibody in pregnant women ,the higher the incidence of HDN ,and the difference of the different antibody titer groups were significant(P<0 .05) .Conclusion:Maternal O type blood ser‐um IgG anti (a) B antibody titer and ABO hemolytic disease of newborn were highly correlated ,dynamic monitoring of maternal type O serum IgG anti (a) B antibody titer has very important clinical value in the prevention and treat‐ment of hemolytic disease of newborn .
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