Objective :To study the role of flow cytometry in the treatment of minimal residual disease of leukemia ,judge its relationship with the curative effect and prognosis .Methods :Selected 56 leukemia patients from Shaanxi Provincial People Hospital ,they were divided into the low risk group ,medium risk group and high risk group on severity ,using flow cytometry method to detect patients’ leukemia minimal residual disease after chemo‐therapy and after chemotherapy of six months .Carry out a one‐year follow‐up and record the recurrence rate .Re‐sults :56 cases had obtained complete remission after therapy ,the difference of positive rates of MRD were statisti‐cally significant (P<0 .05 or P<0 .01) after chemotherapy and after chemotherapy of six months .the high group’s positive rate of MRD was higher than that in low risk group ,medium risk group .the recurrence rate was different between MRD positive group and negative group .Conclusion :The use of flow cytometry detection method for evalu‐ation of curative effect of leukemia minimal residual disease ,early prevention of recurrence ,redetermine the degree of disease risk and adjust the treatment strategy has important significance .%目的：研究流式细胞术方法在检测白血病微小残留病变（MRD）中的作用及地位，判断其与疗效及预后的关系。方法：选择急性淋巴细胞白血病（ALL）初发患者56例，将其按照成人ALL危险分组分为低危组、中危组和高危组三组，在所有患者巩固及维持治疗阶段，每3个月运用FCM 方法检测白血病微小残留病变，对其进行为期一年的随访，记录下复发率。结果：56例白血病患者在诱导化疗后都获得了完全缓解，巩固及维持治疗阶段四次检测的不同疾病危险度的M RD阳性率差异均具有统计学意义（P＜0．05或 P＜0．01），HR组的MRD阳性率要明显高于 LR和M R组；巩固、维持治疗阶段四次检测结果的M RD阳性组和阴性组的复发率比较差异具有统计学意义（P＜0．05）。结论：运用流式细胞术方法检测白血病微小残留病变对评价疗效、提早预防复发、重新确定疾病危险度和调整治疗策略方法有着重要意义。
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