目的：探讨自动变流（Autoflow ）在慢性阻塞性肺病急性发作（AECOPD）并发Ⅱ型呼吸衰竭患者机械通气中的临床应用价值。方法：54例A EC O PD并发Ⅱ型呼吸衰竭患者，经气管插管行机械通气治疗，给予同步间歇指令通气（SIM V ）＋压力支持通气（PSV ），病情稳定后随机分为SIM V-PSV组（对照组）和 SIM V-PSV ＋ AutoFlow 组（治疗组）。继续治疗4～6h ，对两组心率（HR）、平均动脉血压（MAP）、动脉血气（ABG）、浅快呼吸指数（f/VT）、撤机时间、气道吸气峰压（PIP）、气道平均压（Pmean）、气道阻力（R）、胸肺顺应性（C）和分钟通气量（VE）等数据进行统计学分析。结果：治疗组f/V T、撤机时间、Pmean、R低于对照组（ P＜0．05）；PIP低于对照组（ P＜0．01）；C高于对照组（P＜0．01）。结论：AECOPD并发Ⅱ型呼吸衰竭患者机械通气使用Autoflow 既可以保证分钟通气量、降低气道压、减少人-机对抗，在一定程度上还可改善胸肺顺应性、减少患者在IC U住院时间。%Objective :Investigating the clinical value of Autoflow in therapy of mechanically ventilated pa-tients with RFⅡ(type Ⅱ respiratory failure) caused by AECOPD .Methods :When got stable ,54 patients with RFⅡ caused by AECOPD ,who had received treatments of mechanically ventilation under SIMV + PSV mode though tracheal cannula ,were divided into two groups as SIMV-PSV group and SIMV-PSV+Alow group .Then ,after 4~6 hours of continuous treatment ,HR(heart rate) ,MAP(mean arterial pressure) ,ABG(arterial blood gases) ,f/VT (frequency/tidal volume ratio) ,weaning time ,PIP(peak inflation pressure) ,Pmean(mean airway pressure) ,R(air-way resistance) ,C(chest-lung compliance) and VE(minute ventilation) were recorded so that comparisons could be done .Results :Compared with SIMV-PSV group ,f/VT ,weaning time ,Pmean and R in SIMV-PSV+ Autoflow group were lower significantly (P<0 .05) ,PIP was lower significantly (P<0 .01) ,and C was higher significantly (P<0 .01) .Conclusions :Autoflow in mechanically ventilation treatments could ensure minute ventilation ,decrease airway pressure and improve man-machine counteraction ,and in part ,could also improve chest-lung compliance and decrease hospitalization time in ICU .
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