目的：评价血清降钙素原（PCT ）在新生儿感染性疾病的早期诊断、鉴别、治疗效果评价中的临床意义。方法：230例患儿根据出院诊断分为一般感染组（n＝130例）和重症感染组（n＝100例），并于入院时和治疗后72h分别测定血清PCT 、Hs-CRP 以及WBC。结果：PCT 阳性重症感染组91例，一般感染组78例，两组相比有统计学意义（P＜0．05）。重症感染组Hs-CRP阳性72例，一般感染组Hs-CRP阳性54例，两组相比有统计学意义（P＜0．05）。一般感染组外周血WBC升者高26例，重症感染组白细胞升高28例，两组相比无统计学意义（P＞0．05）。组内比较，PCT的阳性率明显大于Hs-CRP及外周血WBC（P＜0．05）。治疗后血清PCT 下降较 Hs-CRP及白细胞快（P＜0．05）。结论：监测PCT 水平对于新生儿细菌感染性疾病的早期诊断、病情危重程度、疗效评估具有指导意义。%Objective :To evaluation the clinical significance of serum procalcitonin (procalcitonin ,PCT) in the early diagnosis of neonatal infectious diseases ,identification and clinical effects .Methods:230 newborns suffered infectious disease were divided into general infectious group (n=130) and severe infectious group(n=100) .PCT and and the white blood cell from every cases on admission and 72 hours after treatment were determined .Results :In se-vere infectious group ,there are 91 cases with positive PCT (the positive rate 91% ) .78 cases with positive PCT in general infections group ,there was statistically significant difference in two group (P<0 .05) .HS-CRP positive 72 cases in severe infectious group(the positive rate 72% ) ,there were 54 cases with Hs-CRP positive in general group , there was statistically significant difference in two group too (P<0 .05) .28 cases with increasing white blood cell in severe infectious group ,26cases in general infectious group ,there was no statistically significant difference in two groups(P>0 .05) .Within the two groups ,the positive rate of the PCT was significantly greater than that in Hs-CRP and WBC(P< 0 .05);Compared with Hs-CRP and WBC ,PCT drop fast after treatment ( P< 0 .05) .Conclusion :There is some guidance for monitoring PCT in early diagnosis severity and evaluation the effect in neonatal infectious disease .
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