目的:探讨川崎病(KD)急性期外周血糖皮质激素受体(GR)α、β水平的变化,为其选择糖皮质激素(GC)治疗提供理论依据.方法:采用ELISA法检测38例急性期KD患儿静脉注射丙种球蛋白(IVIG)前后血中GRα和GRβ水平,并与20例正常对照组进行比较.结果:IVIG静注前KD患儿GRα水平与对照组比较无显著性差异(P＞0.05);IVIG后第3天、7天内,GCRα水平较对照组明显下降(P＜0.01).KD患儿GRβ水平在IVIG治疗前后较对照组显著降低(P＜0.01).KD冠状动脉异常组与冠状动脉正常组治疗前后GRα、GRβ水平比较无显著性差异(P＞0.05).结论:KD急性期及早给予外源性GC,则可以发挥更强的抗炎作用.%Objective : To investigate the change of glucocorticoid receptor including glucocorticoid recep -tor-α (GR-α) and glucocorticoid receptor-β(GR-β) in peripheral blood in patients with Kawasaki disease (KD), for provide a theoretical basis of the glucocorticoid (GC ) therapy . Methods : The levels of GR-a and GR-β were measured using ELISA respectively in 38 patients with KD before and after IVIG and 20 healthy children (control group) . Results : There was no difference in the level of GR-a in KD patients and the control group (P>0 .05), But it was significantly lower (P< 0 .01) at 3 and 7 days after intravenous immunoglobulin(IVIG) . Before and after IVIG , the GR-β levels were significantly lower in KD patients than in the control group (P < 0 .01). The level of GR-aand GR-βdiffered between patients with and without dilated coronary arteries . Conclusion : The results suggest that exogenous glucocorticoid can play an important role in the process of anti-inflammatory in the acute KD .
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