Objective: To investigate the status of fatigue and correlates of fatigue among early stage NSCLC survivors for 1~5 years. Methods :Selected 290 cases of patients who with early-stage non-small cell lung cancer that treatment in our hospital between 2007 ~ 2011 for the study. To investigate the patients after treatment including:Simplify fatigue scale, Canovschi function of gauges, International physical activity questionnaire, Basic breathing difficulty index score, Hospital anxiety and depression scale. For differences between patients with different degree of fatigue function using Chi square test,Contact fatigue and risk factors of degree we use Spearman rank correlation and Logistic regression analysis to evaluate. Results:Incidence of postoperative fatigue in patients with 59. 8% ,21. 1% dysfunction happened in patients with moderate and severe fatigue and 9. 6% has an obvious dysfunction in mild fatigue or fatigue-free (P = 0. 02). In the multivariate logistic regression analysis, NSCLC survivors with pulmonary disease (OR: 2.34,CI: 1.08-4.99), depressive symptoms (OR: 6.39,CI: 2.42-17.35) and anxiety symptoms (OR; 2. 45,CI: 1. 13-4. 87) were more likely to report experiencing significant fatigue, while those who met physical activity guidelines (OR: 0. 27,CI: 0. 11-0. 73) reported less fatigue. Conclusion:For early-stage NSCLC patients, After operation,Most exist within 1-5 fatigue;More prone to dysfunction in patients with moderate and severe fatigue. Anxiety, depression and fatigue symptoms in patients with lung complications and are closely related, Treatment should be a comprehensive treatment approach.%目的:探讨我院早期非小细胞肺癌患者治疗后1～5年疲劳情况并分析相关因素.方法:选取我院2007～2011年间治疗的290例早期非小细胞肺癌患者为研究对象,对患者在治疗后进行调查包括:简化疲劳量表、卡诺夫斯基功能状况量表、国际体力活动量表、基础呼吸困难指数评分及医院焦虑抑郁量表.对于不同程度疲劳病人功能状态之间的差异应用卡方检验,疲劳和各种危险因素的联系程度我们使用Spearman秩相关和Logistic多元回归分析进行评价.结果:患者术后疲劳发生率59.8％,中、重度疲劳患者中21.1％具有功能障碍,9.6％的轻度疲劳或无疲劳者具有明显功能障碍(P=0.02).Logistic多元回归分析提示合并肺脏疾病(OR:2.34,置信区间:1.08-4.99)、抑郁症状(OR:6.39,置信区间:2.42-17.35)、焦虑症状(OR:2.45,置信区间:1.13-4.87)是疲劳的独立危险因素,而体力活动(OR:0.27,置信区间:0.11-0.73)具有预防疲劳的作用.结论:早期NSCLC病人术后1～5年内大部分存在疲劳现象;中、重度疲劳患者更容易出现功能障碍.焦虑、抑郁和肺脏合并症与患者的疲劳症状密切相关,治疗上应采取综合的治疗方式.
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