Objective: To discuss the relationship between increasing of Scrum high sensitive C reactive protein (hs-CRP) of type 2 diabctc mcllitus (T2DM) patient and occurancc of diabetic nephropathy. Methods: Divided 241eases of T2DM patients into 3 groups according to the consistency of the scrum CRP: 81 cases for Group A, CRP3mg/L. Meanwhile, maked 60 healthy people as normal control group . Tested their CRP, urinary albumin excretion rate (UAER), fast blood glucose (FBG) ,fasting insulin (INS) ,glycosylatcd hemoglobin (HbA1 c) , triglyccridc (TG) and Total cholesterol (TO every 3 months for 24 months. Results:The higher the level of the hs-CRP , the more possibility the diabetic nephropathy occurcd. Comparing with the normal control group , the levels of hs-CRP, UAER, FBG, HbA1 c, INS,TG,TC and Homcostatic model assessment for insulin resistance (HOMA-IR) of all patients in the three groups were increased, the difference was statistically significant. Comparing pro-observation with post-observation of all patients, the levels of hs-CRP, UAER, FBG, HbA, c, INS, TG, TC and HOMA-IR were increased, the difference was statistically significant. Hs-CRP was positive correlated with UAER and HOMA-IR on T2 DM patient. Conclusion; Hs-CRP can be regarded as prognosis index of diabetic Nephropathy for T2DM patient.%目的:探讨2型糖尿病(T2DM)患者血清超敏C-反应蛋白(hs-CRP)升高与糖尿病肾病发生的关系.方法:根据血清CRP的浓度,将241例T2DM患者分为三组:A组81例,CRP≤1mg/L;B组93例,1mg/L＜CRP≤3mg/L;C组67例,CRP＞3mg/L.另外设正常对照组60例.每3个月检测其hs-CRP、尿白蛋白排泄率(UAER)、空腹血糖(FBG)、空腹胰岛素(INS)、糖化血红蛋白(HbA1c)、甘油三脂(TG)、胆固醇(TC),连续观察24个月.结果:hs-CRP水平越高其发生糖尿病肾病的可能越大.各糖尿病组患者与对照组比较,hs-CRP、UAER、FBG、HbA1c、INS、TG、TC、稳态模型胰岛素抵抗指数(HOMA-IR)等水平升高,差异有统计学意义,各糖尿病组患者观察后与观察前比较,hs-CRP、UAER、FBG、HbA1c、INS、TG、TC、HOMA-IR等水平升高,差异有统计学意义.在T2DM患者中,hs-CRP与UAER、HOMA-IR呈正相关.结论:hs-CRP可作为T2DM患者发生糖尿病肾病的预测指标.
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