Objective: To study the protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats. Methods: 20 rats were randomly divided into two groups with 10 rats each group. The two groups were performed basic anesthesia with ketamine (1mg/kg). sham surgery for control group,while experimental group were inhalationally anesthetized with Isoflurane to maintain anesthesia during surgery in the same time. In two groups after hepatic ischemia-reperfusion, lung lavage fluid and lung tissue were sampled. Observed morphological changes of the lung tissues and determined NF-κB in lung tissue and lavage fluid. Results : Isoflurane anesthesia during hepatic ischemia-reperfusion in rats was effective in reducing NF-κB in lung tissue and lavage fluid,and lung tissue damage became attenuated. Conclusion:lsoflurane was effective to lung injury from hepatic ischemia-reperfusion in rats.%目的:探讨异氟烷对大鼠肝缺血再灌注后肺损伤的保护作用.方法:将20只SD大鼠随机分为两组,每组10只.两组均用氯胺酮(1mg/kg)基础麻醉.对照组进行假手术,吸入组应用异氟烷持续吸入维持麻醉后进行手术,肝脏缺血再灌注后取肺脏灌洗液以及肺组织标本.测定NF-κB的含量以及肺组织形态学观察.结果:异氟烷对实验动物维持麻醉,可以有效地降低肺组织以及肺泡灌洗液中NF-κB的含量,肺组织损伤性变化减轻.结论:异氟烷对大鼠肝缺血再灌注肺组织损伤具有明显的保护作用.
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