D - valine as raw material,by the bok protection,amidation,cyclization and methylation,target product purity of 98% is obtained by high vacuum distillation( R) - 2,5 - dihydro - 3,6 - dimethoxy - 2 - isopropyl piperazine,the total yield of 46. 8% . Through technology improvement simplifies the operation,reduce cost,reduce the reaction conditions,more suitable for industrial production requirements.%以 D -缬氨酸为原料，经 BOC 保护，酰胺化，环合和甲基化，通过高真空精馏得到目标产物纯度达到98％的（R）-2，5-二氢-3，6-二甲氧基-2-异丙基哌嗪，总收率46.8％。通过工艺改进简化了操作，降低成本，降低反应条件，更加适合工业化生产要求。
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