The common problems and maintenance during operation of high performance liquid chromatography( HPLC) were stated generally from the perspective of pressure of pump,baseline,peek and the retention time.%从泵压、基线、峰形及保留时间四方面出发，对高效液相色谱仪使用中常见的故障及如何排除故障、如何维护仪器进行综述。
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