Objective To investigate the expression and clinical significance of CD68 and vascular endothelial growth factor (VEGF)in breast cancer tissues. Methods Immunohistochemistry was used to detect the expression of CD68 and VEGF in 230 cases of breast cancer tissues and the corresponding adjacent tissues. The relationship of the expression of two proteins with the clinicopathological parameters and the recurrence of breast cancer was analyzed. Meanwhile,the correla-tion between the two proteins was also analyzed. Results The positive rates of CD68 and VEGF in the breast cancer tis-sues were significantly higher than those in the adjacent tissues (both P < 0. 01). The positive rate of CD68 protein in the breast cancer was closely related to the clinical stage,lymph node metastasis,and ER status of breast cancer patients (P <0. 05). The positive rate of VEGF protein in the breast cancer was closely related to the ER status of breast cancer patients (P < 0. 05). The positive rates of CD68 and VEGF proteins in the recurrent patients were significantly higher than those in the non recurrent patients (both P < 0. 05). The expression of CD68 protein was positively correlated with the expression of VEGF (r s = 0. 397,P < 0. 01). Conclusion The expression of CD68 protein and VEGF protein increase in the breast cancer tissues,and they may be involved in the occurrence,development,and recurrence of breast cancer.%目的 探讨CD68和血管内皮生长因子(VEGF)在乳腺癌组织中的表达变化及其临床意义.方法 采用免疫组化法检测230例份乳腺癌组织及相应癌旁组织中CD68和VEGF的表达,分析二者表达与乳腺癌临床病理参数、乳腺癌复发的关系以及二者表达的相关性.结果 乳腺癌组织中CD68蛋白、VEGF蛋白阳性表达率均高于癌旁组织(P均<0.01).CD68蛋白阳性表达与乳腺癌患者的临床分期、淋巴结转移、雌激素受体(ER)相关(P<0.05).VEGF蛋白阳性表达与乳腺癌患者的ER相关(P<0.05).CD68与VEGF蛋白在乳腺癌复发患者中的阳性表达率均高于未复发者(P均<0.05).CD68蛋白与VEGF蛋白的表达呈正相关(r s=0.397,P<0.01).结论 乳腺癌组织CD68蛋白、VEGF蛋白表达升高,其二者可能协同参与了乳腺癌的发生、发展及复发.
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