目的 观察肾细胞癌(简称肾癌)的临床流行病学特征,探讨其预后的相关影响因素.方法 回顾性分析2003年1月～2011年12月121例肾癌患者行手术治疗的临床资料.采用Kaplan-Meier法对生存率进行描述,采用Log-rank单因素分析及COX多因素分析对预后因素进行评价,所有数据用SPSS17.O统计软件进行处理.结果 肾癌患者术后l、3、5年总体生存率分别为94％、86％、70％,平均生存期为79.96个月.单因素分析显示,年龄、病理分级、TNM分期病理类型、淋巴结转移、静脉瘤栓、糖尿病、是否有症状这8项因素与预后有关(P均＜0.05).COX多因素分析显示,仅有病理分级、TNM分期、淋巴结转移、静脉瘤栓4项因素与肾癌的预后有关(P均＜0.05).结论 病理分级、TNM分期等是肾癌预后的独立影响因素.%Objective To explore the clinical epidemiological characteristics of the renal cell carcinomas( RCC) and their prognostic factors. Methods A retrospective review of 146 patients with RCC after nephrectomy between January 2003 and December 2011 was performed. The survival rate was estimated using the Kaplan Meier method, and Log-rank univariate analysis and COX multivariate analysis were used to analyze the relationship between the prognosis and the influencing factors. All data were assessed by SPSS17.0. Results The survival rates of 121 recipients living for 1, 3 and 5 years were 94% , 86% and 70%. The median survival time was 79. 96 months. Single factor analysis showed that age, pathologic stage, TNM stage, histological subtypes, symptoms, venous thrombus, lymphatic metastasis, diabetes mellitus were significant prognostic factors (P < 0.05). COX multivariate analysis showed only 4 influencing factors that pathological grading, TNM staging, lymphatic metastasis and venous thrombus were related to RCC prognosis. Conclusion TNM staging, pathological grading, etc. all are independent related factors to RCC prognosis.
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