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首页> 中文期刊> 《山东医药》 >超顺磁性氧化铁纳米粒子的制备、表征及生物相容性研究

超顺磁性氧化铁纳米粒子的制备、表征及生物相容性研究

         
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摘要

Objective To evaluate the preparation, characterization and biocompatibility of Fe3O4 magnetic mnanop-articles for the treatment of tumor by magnetohydrodynamic heat therapy, so to lay the foundations for its application. Methods Fe3O4 magnetic nanoparticles were prepared through co-precipitation method. The appearance, phase constitue, function groups and magnetic susceptibility were characterized by transmission electron microscope ( TEM) , X-RAY powder diffraction (XRD) , scanning electron microscope-energy dispersive spectrum (SEM-EDS) and vibrating sample magnetometer ( VSM) ; MTT assay was used to investigate the in vitro toxicity and hemolysis test was carried out to estimate whether it had blood toxicity; Fe3 O4 suspension was intraperitoneally injected into KM mouse to calculate the acute toxicity; micronu-cleus ( MN) were reckoned to identify whether it was genotoxic. Results TEM showed the shapes of Fe3O4 nanoparticles to be approximately global and the size was estimated to be about 23 nm; XRD comparing with powder diffraction file of spinel Fe3 O4 nanomaterials by JCPDS indicated only spinel pHase; The components of 0 and Fe were determined; the toxicity to L-929 cell was between 0-1 degree and it had no hemolysis activity; No genotoxic effects were found. Conclusion The serf-prepared nanosized Fe3 O4 is a kind of high biocompatibility materials and is suitable for further application in tumor hy-perthermia.%目的 研究用于肿瘤磁流体热疗的超顺磁性氧化铁纳米粒(以下简称纳米粒)的制备、表征及其生物相容性,为其临床应用奠定基础.方法 采用改良的化学共沉淀法制备纳米粒.采用透射电镜( TEM)、X射线粉末衍射(XRD)、能谱分析(SEM-EDS)、振动样品磁强计(VSM)等手段对其形貌、物象、成份、磁性能等表征进行观察；MTT试验评价其体外细胞毒性；溶血试验评价其溶血作用；小鼠腹腔注射纳米粒混悬液测定其急性毒性；微核试验评价其致畸、致突变作用.结果 相关检测结果显示,纳米粒形态规则、密度均匀,粒径约为23 nm；其成分为Fe与O两种元素.纳米粒对L-929细胞的毒性为O～Ⅰ级；无溶血作用及致畸、致突变作用.结论 本研究成功制备了纳米粒；该纳米粒具有良好的生物相容性,在肿瘤热疗领域具有一定应用前景.

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  • 来源
    《山东医药》 |2012年第39期|1-4|共4页
  • 作者

    陈道桢; 项达军; 李向东; 唐秋莎; 许飞; 臧嘉; 张婷; 陆牡丹; 杨岚; 王家俊;

  • 作者单位

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    新疆阿合奇县人民医院;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    新疆阿合奇县人民医院;

    东南大学医学院病理与生理学系;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

    南京医科大学附属无锡妇幼保健院,江苏无锡 214002;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 治疗实验;
  • 关键词

    超顺磁性氧化铁纳米粒; 生物相容性; 磁流体热疗;

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