目的 探讨血管内皮生长因子与sIL-2R在分化型甲状腺癌患者血清中的表达水平及其诊断能力.方法 选择2014年2月至2015年12月于我院头颈外科就诊的甲状腺病变患者66例和健康对照37名,研究对象按病理结果分为分化型甲状腺癌组37例、甲状腺良性肿瘤组29例和健康对照组37名.计量资料采用(x)±s表示,3组间比较采用单因素方差分析,2组间比较采用t检验或q检验.同时,对血管内皮生长因子、sIL-2R以及2项指标联合检测运用ROC曲线分析其对分化型甲状腺癌的诊断能力.结果 分化型甲状腺癌组患者血清中的血管内皮生长因子及sIL-2R的表达水平明显高于甲状腺良性肿瘤组和健康对照组,甲状腺良性肿瘤组的血管内皮生长因子及sIL-2R的表达水平明显高于健康对照组,差异有统计学意义(P＜0.05).血管内皮生长因子、sIL-2R及2项指标联合检测的ROC曲线分析,曲线下面积分别为0.811、0.852、0.915.血管内皮生长因子与sIL-2R在分化型甲状腺癌的不同病理类型中的表达水平差异无统计学意义(P＞0.05).结论 血管内皮生长因子、sIL-2R与两者联合检测可作为鉴别甲状腺良恶性病变的参考指标.%Objective To observe the serum levels and the abilities of diagnosis of VEGF and sIL-2R in the patients with differentiated thyroid cancer.Methods All of the 66 patients with thyroid diseases in our hospital from February 2014 to December 2015 and the 37 cases of healthy people were divided into thyroid benign group,thyroid malignant tumor group and healthy group.Measurement data were expressed by (x)±s.The comparison of three groups of samples were analyzed by one-way ANOVA and the comparison of two groups of samples were analyzed by test.The serum expression levels of VEGF,sIL-2R and the combined detection of VEGF and sIL-2R were evaluated by ROC analysis to evaluate these indexes' abilities of diagnosis.Results In the comparison of three groups of samples,the concentration of serum VEGF and sIL-2R in the thyroid malignant tumor group were higher than that of the thyroid benign tumor group and the healthy group.The concentration of serum VEGF and sIL-2R in the thyroid benign tumor group were higher than that of the healthy group.The difference was statistically significant(P ＜0.05).The ROC analysis showed that the AUC of VEGF,sIL-2R and the combination of these two indexes were 0.811,0.852,0.915,respectively.The serum expression levels of VEGF and sIL-2R in the different pathological types of thyroid malignant tumor had no difference.The difference wasn't statistically significant (P ＞0.05).Conclusion VEGF and sIL-2R can be used for the identification of benign and malignant tumor of thyroid.
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