Objective To investigate Value of the detection of procalcitonin(PCT ) combined with N-termi-nal pro brain natriuretic peptide(NT-proBNP) on prognosis of patients with severe respiratory failure .Methods Ninty-six cases of patients with type Ⅱ respiratory failure were chosen and divided into survived group( n =59) and death group( n=37) .The PCT ,NT-proBNP and APACHE Ⅱ score index were analyzed to study the rela-tionship between PCT ,NT-proBNP and the prognosis of the patients .Results The PCT ,NT-proBNP and A-PACHE-Ⅱ scores in the survival group were lower than those in death group ,there was significant difference be-tween two groups (P<0 .05) .Pearson correlation analysis showed that ,PCT (r=0 .432 ,P=0 .021) ,NT-proB-NP (r=0 .324 , P=0 .031) ,and APACHE Ⅱ scores were statistically correlation .ROC curve analysis showed that PCT ,NT-proBNP and APACHEⅡ scores had higher sensitivity and specificity for predicting mortality .In survival group ,PCT and NT-proBNP of 4 cases were greater than the critical value .While among the death group ,PCT and NT-proBNP of 34 cases were greater than the critical value .The sensitivity and specificity of PCT combined with NT-proBNP detection were 79% ,92% of the patients died predictive .Conclusion PCT , NT-proBNP and other indicators has higher value in evaluation of the prognosis in patients with severe respiratory failure ,the combination can improve the detection sensitivity and specificity ,which is worthy of further clinical re-search .%目的 探讨胸腺肽α1辅助治疗慢性阻塞性肺疾病急性加重期 (AECOPD) Ⅱ型呼吸衰竭的临床疗效.方法 按照随机数字表法的分组方法将97例AECOPD Ⅱ型呼吸衰竭患者分为对照组 (常规治疗) 和观察组 (胸腺肽α1辅助常规治疗). ①治疗有效率 :显效+有效. ②一般指标比较 :比较2组患者治疗前后血清C反应蛋白(CRP)、降钙素原(PCT )水平、2组的机械通气时间及2组入住重症监护病房(ICU )的时间. ③统计药物治疗中的不良反应.结果 ①治疗后 ,观察组总有效率为92% ,与对照组(77% )比较差异有统计学意义( P<0 .05). ②2组治疗前血清CRP、PCT水平比较差异无统计学意义(P>0.05);治疗后 ,观察组血清CRP、PCT水平均较对照组改善 ,2组比较差异均有统计学意义(P<0.05).观察组机械通气时间及入住ICU时间均优于对照组 ,2组比较差异有统计学意义(P<0.05). ③观察组未见明显不良反应 ,患者耐受性良好.结论 胸腺肽α1辅助治疗AECOPD Ⅱ型呼吸衰竭患者 ,可改善患者的炎症反应症状 ,提高临床治疗有效率 ,值得临床推广应用.
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