Objective To study the effect of endotoxin on p regnant rat′s urinary albumin excretion and look for its mechanism.Meth od Through rat′s tail vein endotoxin (1.0 μg/kg，n=13) or saline solution (1.0 mL/kg，n=7) was infused on the day 14 of pregnancy.Albuminuria was measured in these rats.Results A significant urinary albumin excretion (P＜0.01) was observed in endotoxin-treated pregnant animals,in contrast to control pregnant rats receiving saline solution.Conclusion Endotoxi n may induce pregnant rat′s renal injury,and make significantly increased album in excretion in the animals.%目的 研究内毒素对孕鼠蛋白尿的影响，并探讨其发生机制。方法 在鼠妊娠的第14天，沿尾静脉分别注入内毒素(1.0 μg/kg)13只，注入生 理盐水(1.0 mL/kg)7只。测尿蛋白含量。结果 孕鼠中内毒素注射组尿蛋白 含量明显较生理盐水组增高(P＜0.01)。结论 内毒素可损 伤孕鼠肾脏使尿蛋白排泄量明显增加
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