To investigate the effects of Mangosteen Capsule on the lipid liver fat content and hemorrheology in rabbits with hyperlipidemia.The rabbits were divided into 6 teams,including normal control group;hyperlipidemia model group;low-dose group,middle-dose group and high-dose group of Mangosteen Capsule (30mg/kg,60mg/kg,120mg/kg),and Xuezhikang Capsule-treated group.The rabbits in normal control were fed with normal fodder,other rabbits were given high cholesterol feed,for six weeks.The animals were weighed after administration once weekly;took the blood by ear vein every two weeks and tested the contentss of TC/HDL-C,TC and LDL-C in serum.After administration,took the blood of rabbits by heart and detected the whole blood viscosity,plasma viscosity and hematocrit;and the contentss of TC and TG in hepatic tissue.Compared with normal control,the contentss of LDL-C,TC and TC/HDL-C in serum of rabbits in model group increased,and there was significant difference;in comparison with model group,the low whole blood viscosity,high whole blood viscosity and plasma viscosity all decreased,in low-dose group,middle-dose group and high-dose group of Mangosteen Capsule;the high whole blood viscosity and hematocrit declined obviously;the contents ofTC,LDL-cho,TC/HDL-cho and TG in serum decreased as well;the contents of TC and TG in liver decreased,which led to the remarkable decrease of liver coeeficient.The contents of TC/HDL-C decreased significantly,which is better than Xuezhikang Capsule-treated group (P ＜ 0.05).The prophylactic administration of Mangosteen capsule can inhibit the formation of experimental hyperlipidaemia in rabbit significantly.,and improve the characteristics of hemorheology of experimental hyperlipidaemia rabbit.%考察莽吉柿胶囊对高脂血症家兔脂质水平和血液流变学的影响.试验分为正常对照组、高脂模型组、阳性对照药血脂康胶囊组(200mg/kg)及莽吉柿胶囊低剂量组(30mg/kg)、中剂量组(60mg/kg)、高剂量组(120mg/kg)6组.对照组动物饲以常规饲料,其余组动物均饲以高胆固醇饲料.共给药6周(正常对照组、高脂模型组除外).每周称量动物体重1次.每2周耳缘静脉取血,测定血清中血清总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)、TC和低密度脂蛋白胆固醇(LDL-C).给药周期结束,心脏取血,测定全血黏度、血浆黏度和红细胞压积;并测定肝组织中TC和甘油三酯(TG).结果,与正常组比较,模型组家兔血清LDL-C、TC和TC/HDL-C等明显增加,差异显著(P＜0.05);与模型组比较,莽吉柿胶囊高剂量组、中剂量组、低剂量组的全血低切黏度、全血中切黏度和血浆黏度均降低;全血高切黏度和红细胞压积明显降低;血清中TC、LDL-C、TC/HDL-C和TG降低;肝脏中TC和TG降低,肝脏系数明显减小.高剂量组血清中TC/HDL-C明显降低,降低TC和LDL-C的强度优于阳性对照药组(P＜0.05).莽吉柿胶囊预防性给药可明显抑制家兔实验性高脂血症的形成,改善实验性高脂血症家兔的血液流变学特性.
展开▼
机译：A aplica莽茫o da terapia comunit谩ria na interven莽茫o com adolescentes: novas estrat茅gias de preven莽茫o e promo莽茫o / Community therapy application in intervention with adolescents: new strategies for prevention and promotion
机译：Indicadores de Altera莽茫o Hidrol贸gica no Alto Rio Paran谩: Interven莽玫es Humanas e Implica莽玫es na Din芒mica do Ambiente Fluvial / Indicators of Hydrologic Alteration in the High Parana River Catchment: Human Interventions and Implications for Dynamic of the Fluvial Environment
