Objective To explore the factors that might affect the penetration and their effects on the permeability of in-filtrants in acid corrosion of youngteeth.Methods 48 extracted youngmandibular incisors were placed 45 d in the decal-cification solution to establish early caries model (Department of Stomatology, Heilongjiang Hospital, September 2015-March,2016), and then randomly divided into 16 groups, with different resin materials and methods for penetration.Pen-etration depth (PD) and early caries lesions depth (LD) were observed, and the percentage penetration (PP) were calcu-lated by dying infiltration and laser scanning confocal microscopy (CLSM).Analysis of the effect of resin materials and penetration time, etching agents and acid etching time on penetration were performed. Results The two factors of pene-tration time and type of resin materials were proved significantly affected the permeability of infiltrants (P<0.05),and permeability of Icon-infiltrant was found better than Single Bond 2;penetration in 5 min was found better than 3 min. Etching agents, etching time two factors were proved significantly affected the permeability of resin materials(P>0.05). Conclusion Permeability of Icon-infiltrant in acid corrosion of youngteeth is better than Single Bond 2;penetration of resin materials in 5min is better than 3 min.%目的：探讨可能影响渗透剂在牙酸蚀症渗透效果的多种因素以及各因素的作用效果。方法48颗无酸蚀症离体下切牙(2015年9月一2016年3月，黑龙江省医院口腔科)，置于脱矿液中45 d建立酸蚀症模型，再随机分为16组，分别采用不同渗透剂(粘结剂和渗透树脂)和渗透时间(5 min和3 min)、不同酸蚀剂(35%磷酸和15%盐酸)和酸蚀时间(30 s和60 s)进行处理。染料浸染和激光扫描共聚焦显微镜观察渗透剂的渗透深度(PD)和酸蚀症的酸蚀症损深度(LD)，并计算渗透百分数(PP)。结果渗透剂种类(粘结剂和渗透树脂)、渗透时间(5 min和3 min)对渗透剂的渗透性差异有统计学意义(P<0.05)，且相同作用时间下渗透树脂的渗透性优于粘结剂的渗透性；相同渗透剂渗透作用5 min比3 min的渗透效果更好。酸蚀剂种类(30%磷酸和10%盐酸)、酸蚀时间(30 s和60 s)对渗透剂的渗透性差异无统计学意义(P>0.05)。结论在牙酸蚀症相同作用时间下渗透树脂的渗透性优于粘结剂的渗透性；相同渗透剂渗透作用5 min比3 min的渗透效果更好。
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