Objective To determine the incidence of human herpes virus (HHV) 1-4 type including herpes simplex virus type-1 (HSV-1), herpes simplex virus type-2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV) in the saliva of human immunodeficiency virus (HIV)-infected patients. Methods The incidence of salivary HSV-1, HSV-2, VZV and EBV from 245 HIV-seropositive individuals and control group was used to investigate by polymerase chain reaction (PCR) or nested PCR. The data was analyzed by SPSS 18.0 statistical software. Results In the 245 HIV-seropositive individuals, the detection rates of HSV-1, HSV-2, VZV, EBV were 29.0%, 3.3%, 4.1%, 82.0%. In the control group, the detection rates of HSV-1, HSV-2, VZV, EBV were 13.3%, 0, 0, 36.7%. Four HHVs were signi-ficantly more prevalent in the salivas of HIV-seropositive persons than those in the control group (P<0.01). The detec-tion rates of HSV-1, HSV-2, VZV and EBV DNA were no difference between the HIV-positive group with highly active antiretroviral therapy (HA ART) and HIV-positive group without HA ART (P>0.05). Conclusion There is a high prevalence of HHV infection in HIV-infected people in Yunnan. The most common virus are EBV, followed by HSV-1, but VZV and HSV-2 are rarely detected. HHV co-infection is also observed.%目的 探讨人类免疫缺陷病毒(HIV)感染者唾液中人类疱疹病毒(HHV)1～4型即单纯疱疹病毒1型(HSV-1)、单纯疱疹病毒2型(HSV -2)、水痘-带状疱疹病毒(VZV)和EB病毒(EBV)的分布情况.方法 利用聚合酶链反应(PCR)方法对HIV感染者和健康者非刺激性全唾液中HSV-1、HSV-2、VZV和EBV DNA的存在情况进行检测,并采用SPSS 18.0软件建立数据库并进行相关指标的统计分析.结果 在245例HIV阳性患者唾液中,HSV-1、HSV-2、VZV和EBV检出率分别为29.0％、3.3％、4.1％和82.0％; 30例对照组唾液中上述4种病毒检出率分别为13.3％、0、0和36.7％.两组总体检出率比较差异有统计学意义(P＜0.01).高效抗逆转录病毒治疗(HAART)使用后HIV感染者唾液中4种病毒的检出率与未使用HAART的患者差异均无统计学意义(P＞0.05).结论 云南地区HIV感染者HHV有较高的流行率,以EBV最为常见,其次为HSV-1,VZV和HSV-2少见,还存在多种疱疹病毒联合感染.
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