目的:观察芒果苷对神经系统、心血管系统和呼吸系统的影响,明确其一般药理活性,为后续毒理试验提供参考.方法:对小鼠一次按0.24,1.0,3.0 g/kg体重灌胃给予芒果苷后,观察其一般行为表现、姿势、步态、有无流涎、流汗、暴燥、抽搐、肌颤等变化,测定其自主活动次数、协调运动情况和阈下睡眠剂量戊巴比妥钠对小鼠睡眠的影响;对Beagle犬一次按0.1,0.7,4.0 g/kg体重十二指肠给予芒果苷后,观测给药后180 min内心电图、血压、呼吸的改变.结果:小鼠一般行为表现、姿势、步态未见有明显改变,也未见有流涎、流汗、暴燥、抽搐、肌颤等现象;自主活动、协调运动情况和戊巴比妥钠阈下睡眠剂量小鼠入睡率均无明显影响.犬心电图、血压、呼吸均无明显变化.结论:在本实验条件下,芒果苷对小鼠精神和神经系统,对犬心血管系统和呼吸系统均无明显影响.%Objective:To observe the effect of mangiferin on nervous system,cardiovascular system and respiratory system,and analyze its general pharmacological effect.Thus providing reference for subsequent toxicological test.Methods:The mice were intragastric administered magiferin of 0.24,1.0 and 3.0 g/kg · bw/ Then changes in its general behavior,posture,gait,salivation,sweating,bruising,and convulsions were recorded.The effects of pentobarbital sodium on mice's sleep were measured.Also,beagle dogs were given mangiferin by duodenum in the dose of 0.1,0.7,4.0 g/kg · bw.Changes in electrocardiogram,blood pressure,and respiratory were recorded after administration.Results:There was no significant change on the general behavior,posture,salivation,sweating,dryness,convulsions,muscle fibrillation of rats.There was no significant effect on independent activities,coordination of exercise and the sleep rate of mice on the sub-threshold sleep dose of pentobarbital sodium.Similarly,there was no significant change on dog electrocardiogram,blood pressure,and breathing.Conclusion:Under the experimental conditions,mangiferin has no significant effect on the mental and nervous system of mice or the cardiovascular system and respiratory system of dog.
展开▼
