Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in a 77-year-old man: A case report

Zi-Gan Xu; Wei-Long Li; Xi Wang; Shu-Yuan Zhang; Ying-Wei Zhang; Xing Wei; Chun-Di Li; Ping Zeng; Shao-Dong Luan

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Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in a 77-year-old man: A case report

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BACKGROUND Systemic lupus erythematosus(SLE)and antineutrophil cytoplasmic antibodyassociated vasculitis(AAV)are classically thought to cause renal impairment and small vessel vasculitis with different pathophysiologies.Their overlap constitutes a rare rheumatologic disease.To date,only dozens of such cases with biopsyproven glomerulonephritis have been reported worldwide typically in women of childbearing age.Here,we present a unique clinical case due to its rarity and individualized treatment of a Chinese man in his eighth decade of life.CASE SUMMARY A 77-year-old man was admitted to several hospitals for shortness of breath and received nonspecific treatments over the past 3 years.As his symptoms were not completely relieved,he visited our hospital for further treatment.Laboratory examinations revealed kidney dysfunction,severe anaemia,hypocomplementemia,glomerular proteinuria,and microscopic haematuria.Antinuclear antibodies,as well as anti-dsDNA antibodies,were positive.Computed tomography of the chest showed right pleural effusion.Renal biopsy was performed,and histology suggested crescentic glomerulonephritis,pauci-immune type.After treatment with plasmapheresis,glucocorticoid,and cyclophosphamide,the disease was in remission,and the patient remained in a stable condition for over 3 years post-hospital discharge.CONCLUSION Due to its complexity and rarity,SLE and AAV overlap syndrome is easily misdiagnosed.An accurate diagnosis and treatment at the earliest stage may significantly improve the condition and reduce irreversible organ injury.

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来源
《世界临床病例杂志》 |2021年第3期|P.707-713|共7页
作者
Zi-Gan Xu; Wei-Long Li; Xi Wang; Shu-Yuan Zhang; Ying-Wei Zhang; Xing Wei; Chun-Di Li; Ping Zeng; Shao-Dong Luan;
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作者单位

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

Department of Nephrology Shenzhen Longhua District Central Hospital Shenzhen 518110 Guangdong Province China;

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原文格式 PDF
正文语种 chi
中图分类全身性疾病;
关键词
Systemic lupus erythematosus; Antineutrophil cytoplasmic antibodyassociated vasculitis; Overlap syndrome; Elderly male; Renal insufficiency; Case report;

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Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in a 77-year-old man: A case report

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