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首页> 中文期刊> 《世界临床病例杂志》 >Clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic

Clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic

         
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摘要

BACKGROUND Since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic,numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis,but it has not been established if there are specific clinical characteristics of encephalitis/meningitis associated with SARS-CoV-2 infection.AIM To identify the specific clinical features of cases of encephalitis/meningitis associated with SARS-CoV-2 infection in the context of this virus infection pandemic and investigate their relationship with SARS-CoV-2 infection.METHODS We searched PubMed,and included single case reports and case series with full text in English,reporting original data of coronavirus disease-19(COVID-19)patients with encephalitis/meningitis and a confirmed recent SARS-CoV-2 infection.Clinical data were extracted.RESULTS We identified 22 articles(18 single case reports and 4 case series)reporting on a total of 32 encephalitis/meningitis patients with confirmed SARS-CoV-2 infection.SARS-CoV-2 infection was confirmed through reverse transcriptase-polymerasechain-reaction(RT-PCR)in 96.88%of cases.A total of 22(68.75%)patients had symptoms of SARS-CoV-2 infection in about 1 wk(7.91 d)preceding the onset of neurologic symptoms.The most common neurological symptoms were consciousness disturbance(59.38%),seizure(21.88%),delirium(18.75%),and headache(18.75%).Four cases were confirmed by positive RT-PCR results in cerebrospinal fluid(CSF),one was confirmed by positive RT-PCR results in postoperative brain tissue,and one by the presence of SARS-CoV-2 antibodies in CSF.The mainly damaged targets identified by neuroimaging included the temporal lobe(15.63%),white matter(12.5%),frontal lobe(9.38%),corpus callosum(9.38%),and cervical spinal cord(9.38%).Eighty percent of patients had electroencephalograms that showed a diffuse slow wave.Twenty-eight(87.5%)patients were administered with specific treatment.The majority(65.63%)of patients improved following systemic therapy.CONCLUSION Encephalitis/meningitis is the common neurological complication in patients with COVID-19.The appropriate use of definitions and exclusion of potential similar diseases are important to reduce over-diagnosis of SARS-CoV-2 associated encephalitis or meningitis.

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  • 来源
    《世界临床病例杂志》 |2021年第5期|P.1058-1078|共21页
  • 作者

    Liang Huo; Kai-Li Xu; Hua Wang;

  • 作者单位

    Department of Pediatrics Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China;

    Department of Pediatric Neurology Children’s Hospital Affiliated to Zhengzhou University Zhengzhou 450018 Henan Province ChinaDepartment of Pediatric Neurology Henan Children’s Hospital Zhengzhou 450018 Henan Province China;

    Department of Pediatric Neurology Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 传染病;
  • 关键词

    COVID-19; SARS-CoV-2; Encephalitis; Meningitis; Clinical features; System review;

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