Preeclampsia - What is to blame？ The placenta, maternal cardiovascular system or both？

Dimuthu Vinayagam; Karin Leslie; Asma Khalil; Baskaran Thilaganathan

首页> 中文期刊> 《世界妇产科杂志》 >Preeclampsia - What is to blame？ The placenta, maternal cardiovascular system or both？

Preeclampsia - What is to blame？ The placenta, maternal cardiovascular system or both？

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

cqvip:Preeclampsia(PE)is a pregnancy-specific syndrome,complicating 2%-8% of pregnancies.PE is a major cause of maternal mortality throughout the world with 60000 maternal deaths attributed to hypertensive disorders of pregnancy.PE also results in fetal morbidity due to prematurity and fetal growth restriction.The precise aetiology of PE remains an enigma with multiple theories including a combination of environmental,immunological and genetic factors.The conventional and leading hypotheses for the initial insult in PE is inadequate trophoblast invasion which is thought to result in incomplete remodelling of uterine spiral arteries leading to placental ischaemia,hypoxia and thus oxidative stress.The significant heterogeneity observed in pre-eclampsia cannot be solely explained by the placental model alone.Herein we critically evaluate the clinical(risk factors,placental blood flow and biomarkers)and pathological(genetic,molecular,histological)correlates for PE.Furthermore,we discuss the role played by the(dysfunctional)maternal cardiovascular system in the aetiology of PE.We review the evidence that demonstrates a role for both the placenta and the cardiovascular system in early-and late-onset PE and highlight some of the key differences between these two distinct disease entities.

著录项

来源
《世界妇产科杂志》 |2015年第4期|P.77-85|共9页
作者
Dimuthu Vinayagam; Karin Leslie; Asma Khalil; Baskaran Thilaganathan;
展开▼
作者单位

Fetal Maternal Medicine Unit;

Lanesborough Wing;

St George＇s Hospital;

Tooting;

London SW17 0QT;

United Kingdom;

Fetal Maternal Medicine Unit;

Lanesborough Wing;

St George＇s Hospital;

Tooting;

London SW17 0QT;

United Kingdom;

Fetal Maternal Medicine Unit;

Lanesborough Wing;

St George＇s Hospital;

Tooting;

London SW17 0QT;

United Kingdom;

Fetal Maternal Medicine Unit;

Lanesborough Wing;

St George＇s Hospital;

Tooting;

London SW17 0QT;

United Kingdom;

展开▼
原文格式 PDF
正文语种 CHI
中图分类 R972.4;
关键词
子痫前期; 妊娠; 生殖健康; 临床分析;

相似文献

中文文献
外文文献
专利

Preeclampsia - What is to blame？ The placenta, maternal cardiovascular system or both？

摘要

著录项

相似文献

相关主题

期刊订阅