Background:disease(BD)is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective:The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and methods:Seventeen patients with BD within a pediatric age group were studied since 1997.Results:Boys :girls ratio was 12:5.Familial cases were very frequent(45%).Oral aphthous ulcers were presentin all patients(100%),genital aphthous ulcers were present in 16(94%),ocular lesions in 4(24%),erythema nodosum in 3(18%),papulopustules in 8(47%),joint symptoms in 13(76%),mild gastrointestinal symptoms in 2(12%),neurological involvement in 2(12%),positive pathergy reactions in 13(76%),and thrombophlebitis in 1(6%).We used colchicine,system iccorticosteroids,cyclosporine,nonsteroidal anti-inflammatory drugs,sulfasalazine,and topical agents for the treatment of children with BD.Conclusion:The findings of BD in children are similar as in adults,but the frequency of familial cases is significantly higher.
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