目的：探讨非酒精性脂肪性肝病的临床特征、危险因素和与代谢综合征的关系，为实施干预措施提供依据。方法非酒精性脂肪肝患者83例（脂肪肝组），检测肝功能、体重指数、腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白、尿酸，并与健康体检者83例（对照组）比较。结果脂肪肝组血清转氨酶高于对照组（P<0.05）。脂肪肝组的体重指数、腰围、血压、空腹血糖、甘油三酯、尿酸指标显著高于对照组（P<0.01）；高密度脂蛋白指标低于对照组（P<0.01）；非酒精性脂肪性肝病易伴发肥胖、高血压、脂血异常、糖尿病和代谢综合征。结论非酒精性脂肪性肝病与机体代谢紊乱相关，属代谢综合征的组成部分，胰岛素抵抗是非酒精性脂肪性肝病形成的主要危险因素，健康的生活方式是防治非酒精性脂肪性肝病的关键。%ObjectiveTo investigat the clnicalfeatures and related risk factors of nonalc- oholic fatty liver disease(NAFLD),the relationship between metabolic syndrome(MS)and NAFLD.Methoels 83 patients with NAFLD verified by B ultrasound or CT and 83 control subjects were enrolled in this study.Measurement of liver function,body mass index(BMI),waistline(WL),bloodpressure(BP),fasting plasmaglucise (FPG),triglyceride(TG),high-dense lipoprotein chotesterol(HDL-C),uric acid(UA)were done.Results Levels of serum ALT and AST were significantly higher in fatty liver patients than those in controls(P<0.05). BMI,WL,BP,FPG,TG,UA were significantly higher in fatty liver patients than those in controls(P<0.01). HDL-C was significantly lower in fatty liver patients than those in controls(P<0.01). Obesity,high blood pressure,hyperlipidemia,diabetes mellitus and MS were syndromes of NAFLD.Conclusion NAFLD is a part of metabolic,the important risk factors for forming fatty liver are insulin resistance. Healthy lifestyles are the key factors of the treatment of NAFLD.
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