目的 观察奥氮平治疗含顺铂方案化疗所致迟发性呕吐的疗效.方法 对应用含顺铂方案化疗的86例肺癌患者随机分为治疗组和对照组,每组各43例.对照组给予常规药物治疗呕吐,治疗组是在常规药物的基础上于顺铂应用前一天晚上开始加用奥氮平片10mg口服,每晚一次,连用7d,观察两组迟发性恶心呕吐的发生情况.结果 治疗组和对照组急性恶心、呕吐的发生率分别是16.28%(7/43)和25.58%(11/43),两组比较差异无统计学意义(P>0.05);而治疗组和对照组迟发性恶心、呕吐发生率分别是18.60%(8/43)和67.44%(29/43),两组比较差异有统计学意义(P<0.05),且发生级别治疗组也明显低于对照组.结论 奥氮平对含顺铂方案化疗所致迟发性恶心呕吐疗效确切,其他不良反应不明显.%Objective To observe the efficacy and adverse reactions of olanzapine combined with tropisetron and dexamethasone in preventing the incidence of delayed nausea and vomiting induced by cisplatin. Methods A total of 86 patients with lung cancer were randomly divided into two groups:the olanzapine group was given olanzapine 10 mg for 7 days from the day before chemotherapy. Both the olanzapine group and the control group were given tropisetron and dexamethasone during chemotherapy,The efficacy and adverse reactions of the two groups were recorded. Results The treatment group and the control group of acute nausea and vomiting rate were 16.28%(7/43)and 25.58%(11/43),the two groups had no statistically significant difference (P>0.05);while the treatment group and the control group delayed nausea and vomiting incidence rates were 18.60%(8/43)and 67.44%(29/43), the difference was statistically significant(P<0.05),and the occurrence level of the treatment group was significantly lower than the control group. Conclusion Olanzapine can improve cisplatin-induced nausea and vomiting with well-tolerated adverse reactions.
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