Objective To observe and analyze the influence on cognitive function after laparoscopic surgery of the elderly patients with diabetes mellitus after different concentrations of seven isoflurane anesthesia.Methods 90 elderly patients with diabetes who underwent laparoscopic gastrointestinal surgery were randomly selected from January 2015 to September 2016 in our hospital and randomly divided into low concentration group and high concentration group(n=45),low concentration group patients inhaled 1.5% halothane seven anesthesia, the high concentration group was treated with 3% halothane seven anesthesia,and two groups of patients with cognitive function,blood glucose and serum s100 protein levels were compared.Results There was no significant difference in MMSE score between the two groups before anesthesia(P>0.05);however,the 48h scores of 6h,24h,72h and MMSE in low concentration group were significantly higher than those in control group(P<0.05). The preoperative 1h and postoperative 6h,24h,48h,72h value of blood glucose were compared and had no significant difference of anesthesia in two groups(P<0.05);the two groups of patients with anesthesia difference of serum s100 protein level comparison was not significant,no statistical significance(P>0.05);low concentration group of patients after 6h,24h,72h,48h,serum s100 protein level was significantly lower than that of the high concentration group(P<0.05).Conclusion In seven halothane anesthesia,low concentrations can alleviate the effect on cognitive function in elderly patients with diabetes after surgery and inhibit serum s100 protein level,so that the postoperative cognitive function of patients can recover quickly.%目的 分析不同吸入浓度七氟烷麻醉对老年糖尿病患者术后认知功能的影响.方法 选择2015年1月至2016年9月拟行腹腔镜肠胃手术的老年糖尿病患者90例,采用数字随机法分为低浓度组(n=45)与高浓度组(n=45),低浓度组患者吸入1.5%七氟烷麻醉,高浓度组患者给予3.0%七氟烷麻醉,比较两组患者的认知功能、血糖及血清S100蛋白水平.结果 两组患者麻醉前MMSE评分比较差异无统计学意义(P>0.05);但低浓度组患者术后6h、24h、48h、72h的MMSE评分显著高于高浓度组(P<0.05).两组患者麻醉前、术中1h、术后6h、24h、48h、72h的血糖值比较差异无统计学意义(P<0.05);两组患者麻醉前血清S100蛋白水平比较差异无统计学意义(P>0.05);低浓度组患者术后6h、24h、48h、72h血清S100蛋白水平显著低于高浓度组(P<0.05).结论 在七氟烷麻醉中,低浓度的七氟烷吸入麻醉减轻对老年糖尿病患者术后认知功能的影响,抑制患者的前血清S100蛋白水平,患者术后认知功能能够较快恢复.
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