Objective To study the change and Clinical significance of serum Homocysteine (Hcy),Vitamin B12(VitB12) and active Vitamin B12 in Pregnant women. Methods The serum level of Hcy,VitB12 and active VitB12 were detected on 174 pregnant women and 226 late pregnant women,and the relevant line were analyzed by Correlation analyses. Result The level of VitB12 in late pregnant women were significantly lower than in normal pregnant women(P<0.01). The level of VitB12 were Negative correlated with Hcy,while the active vitamin B12 were negative correlated with Hcy in late pregnant women. The ratio of active VitB12/VitB12 were positively correlated with Hcy(r=0.247,P<0.01). Conclusion The ratio of active VitB12/VitB12 should be a new sensitive index to analyze the level of Hcy.%目的：探讨妊娠期妇女血清VitB12、活性VitB12和Hcy的相关性及其临床意义。方法检测174例妊娠中孕和226例妊娠晚孕妇女血清VitB12、活性VitB12和Hcy的水平，并对其相关性进行比较分析。结果晚孕期妇女血清VitB12水平显著低于中孕组（P<0.001）；妊娠中、晚孕期VitB12与Hcy成负相关（P<0.001），活性VitB12在晚孕期与Hcy成负相关，差异有统计学意义（P<0.05）；晚孕期活性VitB12/VitB12比值与Hcy为正相关（r=0.247，P<0.001）；在VitB12正常的孕产妇人群中，ROC曲线显示活性VitB12/VitB12比值对Hcy升高具有更灵敏的检出作用。结论活性VitB12/VitB12比值可作为Hcy升高的一个新指标。
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