Objective The aim of this study is to investigate the expression difference of sera cystatin C level between patients with gastric cancer and contrast volunteers and the determine factors that related. Methods Blood samples were collected from 90 patients with gastric cancer and 46 healthy control subjects. Cystatin C concentration were detected by turbidity measurement and were analyzed by univariate method. The correlation of sera cystatin C concentration to gastric cancer patient’s age,gender,tumor size,tumor TNM stage,differentiation degree,tumor thrombi was analyzed by univariate method. Results Cystatin C levels were significantly lower in the patients with gastric cancer than that in the healthy control subjects(P<0.01). Correlation analyze reveals that the level of Sera Cystatin C was correlated with patient’s age,tumor size,tumor thrombi, differentiation degree of tumor(P<0.05). Cystatin C is not relevant with patient’s gender,tumor TNM stage of gastric cancer(P>0.05). Conclusion Sera cystatin C level in gastric cancer patients was significantly lower than healthy control subjects and reflects the degree of malignant tumor. Sera cystatin C contributes to the early detection,diagnosis of patients with gastric cancer and helps the planning of therapy scheme after surgery.%目的：研究血清半胱氨酸蛋白酶抑制剂C（Cys C）的表达水平在胃癌患者与健康人群中的差异，分析影响其表达水平的相关因素。方法采用比浊法分别检测并比较90例胃癌患者和46例健康对照者中血清Cys C浓度差别，并进一步将胃癌患者血清 Cys C 的浓度与患者年龄、性别、肿瘤大小、肿瘤TNM分期、分化程度、癌栓形成作相关性分析。结果胃癌患者血清Cys C水平低于健康对照者（P<0.01）；相关性分析显示胃癌患者血清Cys C水平与年龄、肿瘤大小、癌栓形成、分化程度相关（P<0.05），与患者性别、肿瘤TNM分期无关（P>0.05）。结论胃癌患者血清Cys C水平低于健康对照者，且血清Cys C水平能反映肿瘤的恶性程度，检测血清中Cystatin C表达水平有助于早期发现判断患者病情并协助制定术后治疗方案。
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