目的：评估冠心病（CAD）合并糖尿病（DM）患者血清胱抑素C（Cys C）水平的变化。方法入选51例经冠状动脉造影检查确诊的CAD患者，病例分为两组：单纯CAD组27例，CAD+DM组24例；测定患者的血清Cys C浓度，采用Gensini积分法定量评估冠状动脉病变程度。比较两组患者血清Cys C水平的差异；分析血清Cys C浓度与冠状动脉病变程度的相关性。结果 CAD+DM组患者血清Cys C水平和Gensini积分高于单纯CAD组（P<0.05）；Pearson相关分析显示，血清Cys C水平与Gensini积分值呈正相关（r=0.33，P<0.05）。结论血清Cys C检测有助于反映冠状动脉病变严重程度。CAD合并DM患者血清Cys C水平较高。%Objective To assess the serum cystatin C(Cys C)levels in coronary artery disease(CAD)patients with diabetes mellitus (DM). Methods A total of 51 angiographically diagnosed CAD patients were included in this study. Patients were divideded into two groups:CAD without DM(n=27)and CAD with DM(n=24). Serum Cys C concentrations were measured. The severity of CAD was calculated using Gensini scoring. Serum Cys C levels in CAD wih DM were compared with those in CAD without DM. The relationship of serum Cys C with the severity of CAD was examined. Results Serum Cys C levels and Gensini score in CAD patients with DM were significiantly higher than those without DM (P<0.05). Pearson correlation analysis revealed that the Cys C levels were positively correlated with the CAD Gensini score(r=0.33,P<0.05). Conclusion Serum Cys C concentration reflects the severity of CAD. Compared with CAD without DM,CAD with DM have higher levels of Cys C.
展开▼
